International experience of using olaparib for metastatic castration-resistant prostate cancer: literature review

نویسندگان

چکیده

The following review presents a problem of metastatic castration-resistant prostate cancer and its association with germline or somatic mutations in homologous recombination repair (HRR). In 2020, olaparib was approved the Russian Federation as monotherapy for genes involved DNA by recombination, after progression on therapy new hormonal drugs. We describe main clinical trials assessing efficacy, safety tolerance patients.

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ژورنال

عنوان ژورنال: Onkourologiâ

سال: 2021

ISSN: ['1996-1812', '1726-9776']

DOI: https://doi.org/10.17650/1726-9776-2020-16-4-197-206